ISCBacademy<https://www.iscb.org/iscbacademy> Modeling Microbe Evolution Due to Immune System Pressure by Nico Pfeifer (University of Tübingen) Today - February 25, 2025, at 3:00 PM CET Microbes are under constant evolutionary pressure from their environment, with the immune system playing a significant role in shaping their adaptation strategies. Viruses, in particular, must evolve to evade immune responses, enabling them to establish persistent infections. A well-studied example is HIV, where viral adaptation to the host's immune system has been extensively modeled using computational methods. In this talk, Nico Pfeifer will explore the computational approaches developed to model viral adaptation and their implications for understanding microbe evolution under immune pressure. The session will cover: * Early computational models of HIV immune adaptation [1] * Recent advances in Bayesian modeling for predicting viral evolution [2] * The impact of founder effects on adaptation predictions * Applications beyond viruses, including resistance prediction for Mycobacterium tuberculosis These insights not only enhance our understanding of viral evolution but also inform strategies for tackling antimicrobial resistance and improving predictive models for microbial adaptation. [1] Carlson, J., Du, V., Pfeifer, N. et al. Impact of pre-adapted HIV transmission. Nat Med 22, 606–613 (2016). [2] Hake, A., Germann, A., de Beer, C. et al. Insights to HIV-1 coreceptor usage by estimating HLA adaptation with Bayesian generalized linear mixed models, PLOS Computational Biology, 19(12): e1010355 (2023). Join the Webinar by logging in to ISCB Nucleus<https://iscb.junolive.co/> ________________________________ Dr. Mattea Müller Project Manager Computational Biology for Infection Research Head of Department: Prof. Alice McHardy Helmholtz Centre for Infection Research GmbH Inhoffenstrasse 7 38124 Braunschweig Germany ________________________________ Helmholtz-Zentrum für Infektionsforschung GmbH | Inhoffenstraße 7 | 38124 Braunschweig | www.helmholtz-hzi.de Vorsitzende des Aufsichtsrates: Frau MinDir'in Prof. Dr. Veronika von Messling, Bundesministerium für Bildung und Forschung Stellvertreter: MinDirig Rüdiger Eichel, Niedersächsisches Ministerium für Wissenschaft und Kultur Wissenschaftlicher Geschäftsführer: Prof. Dr. Josef Penninger - Administrativer Geschäftsführer: Christian Scherf Gesellschaft mit beschränkter Haftung (GmbH) Sitz der Gesellschaft: Braunschweig Handelsregister: Amtsgericht Braunschweig, HRB 477 Unsere Hinweise zum Datenschutz finden Sie hier: https://www.helmholtz-hzi.de/de/service/datenschutz/