1:06 p.m.
ISCBacademy<https://www.iscb.org/iscbacademy>
Modeling Microbe Evolution Due to Immune System Pressure
by Nico Pfeifer (University of Tübingen)
Today - February 25, 2025, at 3:00 PM CET
Microbes are under constant evolutionary pressure from their environment, with the immune
system playing a significant role in shaping their adaptation strategies. Viruses, in
particular, must evolve to evade immune responses, enabling them to establish persistent
infections. A well-studied example is HIV, where viral adaptation to the host's immune
system has been extensively modeled using computational methods.
In this talk, Nico Pfeifer will explore the computational approaches developed to model
viral adaptation and their implications for understanding microbe evolution under immune
pressure. The session will cover:
* Early computational models of HIV immune adaptation [1]
* Recent advances in Bayesian modeling for predicting viral evolution [2]
* The impact of founder effects on adaptation predictions
* Applications beyond viruses, including resistance prediction for Mycobacterium
tuberculosis
These insights not only enhance our understanding of viral evolution but also inform
strategies for tackling antimicrobial resistance and improving predictive models for
microbial adaptation.
[1] Carlson, J., Du, V., Pfeifer, N. et al. Impact of pre-adapted HIV transmission. Nat
Med 22, 606–613 (2016).
[2] Hake, A., Germann, A., de Beer, C. et al. Insights to HIV-1 coreceptor usage by
estimating HLA adaptation with Bayesian generalized linear mixed models, PLOS
Computational Biology, 19(12): e1010355 (2023).
Join the Webinar by logging in to ISCB Nucleus<https://iscb.junolive.co/>
________________________________
Dr. Mattea Müller
Project Manager
Computational Biology for Infection Research
Head of Department: Prof. Alice McHardy
Helmholtz Centre for Infection Research GmbH
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Germany
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